Covid – 8th wave: what is memantine, this miracle substance that turns the virus against itself – L’Indépendant

Covid – 8th wave: what is memantine, this miracle substance that turns the virus against itself – L’Indépendant

We arm it with small molecular warheads that ultimately prevent it from infecting our cells: it’s our revenge on the virus.” details Stuart Lipton, lead author of a study on this drug that could change everything.

More than two and a half years after launch health crisis, virus of Covid-19 it is still being revealed, but also mutating and evolving. Fortunately, while 8th wave It seems to be forming, science continues to understand disease and always discovers other ways to fight. with vaccines, for one, whose latest update has been shown to be effective against the latest versions of Covid-19. with treatment also.

Due, scientists at the Scripps Research Institutebiomedical research center in the United States (California), describe in the online journal Nature anti-Covid effects of a medicines already used to fight against Alzheimer’s disease.

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“Vehicle to its own demise”

“Medications, NMT5described in Nature Chemical Biology on September 29, 2022 applies to SARS-CoV-2 chemicals that can temporarily alter the human ACE2 receptor, a molecule that the virus normally attaches to to infect cells. This means that when the virus is nearby, its way into human cells via the ACE2 receptor is blocked; however, in the absence of virus, ACE2 can function as usual”, it is explained on the Scripps Research website.

“What’s so good about this drug is that we’re turning the virus against itself.”says lead study author Stuart Lipton. “We’re arming it with small molecular warheads that will ultimately prevent it from infecting our cells: it’s our revenge on the virus.”.

Developed in the 1990s for combat Alzheimer’s disease, memantine has proven its effectiveness in animal tests: “Lipton and his team tested a library of compounds similar to memantine in their overall structure, but coated with additional pharmacological warheads. They identified the labeled NMT5 drug candidate as a drug with two key properties: it could recognize and bind to surface pores SARS-CoV-2and could chemically modify human ACE2 using a nitroglycerin fragment as a warhead. The group realized that this could turn the virus into a transport vehicle for its own demise.”.

Confirmed in humans.

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