Cannabis cells grown in bioreactors are 12 times more efficient than natural ones

Cannabis cells grown in bioreactors are 12 times more efficient than natural ones

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The legalization of cannabis and products derived from it is promoted every year, especially for its potential therapeutic uses. Since recently announcing a partnership with former astronaut Chris Hadfield on the potential use of cannabis in space, BioHarvest has made a major breakthrough by cloning and enhancing plant cells: the effects are 12 times stronger than cells obtained directly from the plant. By concentrating active molecules at the cellular level, the lab believes it is making a breakthrough both for therapeutic cannabis, and in resource-friendly and environmentally friendly cultivation methods.

For centuries, generations of natives have traditionally used cannabis for various rituals, but also for its anxiolytic properties that help manage many disorders. Although it is considered a hard drug and is banned in many countries, modern science is now investigating the biomolecular mechanisms induced by the substance for its medical use.

Indeed, previous research has shown that cannabinoids can be used to treat pain, anxiety, sleep disorders, and attention deficit hyperactivity disorder (ADHD). They are also indicated for the relief of therapy-resistant neuropathic pain, certain forms of drug-resistant epilepsy, chemotherapy-related side effects, etc.

The advantage of BioHarvest cloned cells is that the particularly active and sought-after cannabinoids for various therapeutic strategies are concentrated and increased. Normally, some of these active molecules are only found in trace amounts in whole cannabis plants. ” BioHarvest’s achievements in naturally producing important minor cannabinoids at significant biologically active levels combined with high levels of major cannabinoids, all produced with a high level of consistency, represents a significant breakthrough towards the development of effective cannabis-based botanical medicines “, explains Mrs communicated Christopher D’Adamo, director of the Center for Integrative Medicine at the University of Maryland.

Grown in bioreactors in a laboratory in Israel, BioHarvest hemp cells are developed in the same way as other cloned plant products such as Vinia “grapes” that are already commercially available. Like the Vinia product, the company believes it is selling its products directly to consumers in the United States on a federally legal basis. ” The ability to produce unique hemp and hemp-based compositions gives us tremendous flexibility in deciding which markets to pursue, what the optimal product offerings and partnerships would be. ”, says Ilan Sobel, CEO of BioHarvest.

More efficient, cheaper and more environmentally friendly

BioHarvest cannabis, which is the result of cloned cells, has no genetic modification and can be reproduced (or replicated) indefinitely. While regular cannabis is optimally edible only after 14 to 13 weeks, cell culture only takes three weeks to be ready for consumption. Cells grown in a bioreactor under controlled conditions contain 12x more active cannabinoids than the plant.

The original plant would only contain 3% cannabinoids, while the BioHarvest clones contain up to 36%. When it comes to minor or rare cannabinoids, these clones contain significantly high levels. According to laboratory researchers, culture conditions in bioreactors are tightly controlled to modulate the amount of active molecules.

By adjusting the specific conditions to which the cells are exposed, we can create different desired compositions of active substances. says Sobel. ” Which means we can increase or decrease different cannabinoids [composés] “, he adds. The compound can be consumed as is, by smoking, or in the form of pills, drops, gum, etc.

In addition, bioreactor cultivation requires much less water than conventional farming methods. According to the company’s calculations, the need for land will be reduced by 90%, the need for water up to 54 times, and each kilowatt of electricity needed by the bioreactor will produce eight times more active materials than in nature. These parameters can significantly reduce production costs and potentially solve the resource problems of current agriculture.

The conditions inside the bioreactors also make it possible to isolate the young cells in such a way that they are protected from any external contamination (bacteria, fungi, parasites, etc.). Production is thus qualitatively and quantitatively uniform.

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